MODULATING THE GLOBAL RESPONSE REGULATOR, LUXO OF V. CHOLERAE QUORUM SENSING SYSTEM USING A PYRAZINE DICARBOXYLIC ACID DERIVATIVE (PDCAPY): AN ANTIVIRULENCE APPROACH

Vibrio cholerae is a Gram-negative pathogen which causes acute diarrhoeal disease, cholera by the expression of virulence genes through quorum sensing (QS) mechanism.The QS circuit of V.cholerae is controlled by the global quorum regulator, LuxO, which at low cell density (LCD) state produces major virulence factors such as, toxin co-regulated pilu

Background: Although patient education programs impart health-related knowledge that promotes the individual capacity to understand basic health information, there is a dearth of studies that examine the effect of cardiac educational programs on knowledge and satisfaction among patients with coronary artery disease (CAD) in Jordan.Aim: This study a